TOFANIB 5MG TABLET by HORIZON PHARMA contains Tofacitinib 5MG, a prescription Janus kinase (JAK) inhibitor used for the treatment of selected inflammatory and autoimmune conditions. By selectively inhibiting JAK-dependent signaling pathways, Tofacitinib helps reduce abnormal immune activity and inflammation.
Tofacitinib may be prescribed for appropriately selected adults with conditions such as rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. The correct dose depends on the condition being treated, kidney and liver function, other medicines, and the patient's individual risk factors.
✔️ Reduces Inflammatory Activity – Tofacitinib helps suppress specific immune signals responsible for inflammation.
✔️ Rheumatoid Arthritis Management – Used in appropriately selected adults with moderately to severely active rheumatoid arthritis.
✔️ Psoriatic Arthritis Treatment – May help reduce inflammation, joint symptoms, and functional limitations associated with active psoriatic arthritis.
✔️ Ulcerative Colitis Management – Used for certain adults with moderately to severely active ulcerative colitis.
✔️ Helps Control Joint Inflammation – By reducing inflammatory signaling, Tofacitinib may improve joint pain, swelling, and stiffness in inflammatory arthritis.
✔️ Supports Improved Physical Function – Effective disease control can help patients perform everyday activities more comfortably.
✔️ Targeted Immune Modulation – Works through the JAK signaling pathway rather than acting as a conventional steroid.
✔️ Convenient Oral Tablet – Provides an oral treatment option for patients who require JAK-inhibitor therapy.
Tofacitinib belongs to the JAK inhibitor class.
JAK enzymes help transmit signals from inflammatory cytokines to cells. In autoimmune and inflammatory diseases, excessive cytokine signaling can contribute to persistent inflammation.
Tofacitinib inhibits JAK activity, particularly JAK1 and JAK3, reducing signaling from several cytokines involved in immune and inflammatory responses.
🧬 Inflammatory cytokines
⬇️
⚡ JAK signaling
⬇️
🔥 Excess immune activity
⬇️
💊 Tofacitinib blocks JAK signaling
⬇️
📉 Reduced inflammatory signaling
⬇️
🦴 Better control of inflammatory disease
Rheumatoid arthritis (RA) is an autoimmune condition in which the immune system attacks tissues around the joints.
Common symptoms include:
🔹 Joint pain
🔹 Swelling
🔹 Morning stiffness
🔹 Reduced movement
🔹 Fatigue
🔹 Progressive joint damage
Tofacitinib may be prescribed when appropriate treatment with other disease-modifying medicines has not provided an adequate response or has not been tolerated.
It may help improve:
✔️ Joint symptoms
✔️ Physical function
✔️ Disease activity
✔️ Long-term disease control
Psoriatic arthritis is an inflammatory form of arthritis associated with psoriasis.
It can affect:
🖐️ Hands
🦶 Feet
🦵 Knees
🦴 Spine
💅 Nails
🦶 Fingers and toes
Tofacitinib may help reduce inflammatory activity and improve symptoms in appropriately selected adults.
Ulcerative colitis is a chronic inflammatory bowel disease affecting the colon.
Symptoms may include:
🔹 Frequent diarrhea
🔹 Rectal bleeding
🔹 Abdominal discomfort
🔹 Urgency to pass stool
🔹 Bowel inflammation
Tofacitinib can be used in selected adults with moderately to severely active ulcerative colitis, according to an appropriate treatment plan.
🌟 Contains Tofacitinib 5MG – A well-established JAK inhibitor used for selected inflammatory diseases.
🧬 Targeted JAK Pathway – Modifies specific immune signaling pathways involved in inflammation.
💊 Convenient Tablet Form – Oral administration makes treatment convenient when prescribed.
🏭 HORIZON PHARMA – TOFANIB is supplied under the HORIZON PHARMA brand.
📦 30-Tablet Pack – Convenient pack size for ongoing prescribed treatment.
🩺 Specialist-Supervised Treatment – Regular medical monitoring is important for safe use.
⚠️ Take TOFANIB 5MG exactly as prescribed by your doctor.
✔️ Swallow the tablet with water.
✔️ It may generally be taken with or without food.
✔️ Take your doses at the recommended times each day.
✔️ Do not take more than the prescribed amount.
✔️ Do not stop treatment suddenly without discussing it with your doctor.
✔️ If you miss a dose, follow your doctor's or pharmacist's instructions rather than taking an extra dose.
The 5MG strength is used in specific Tofacitinib treatment regimens, but the appropriate dose varies depending on the medical condition.
Your doctor may consider:
🩺 The condition being treated
🫘 Kidney function
🧬 Liver function
🧓 Age
💊 Other medicines
🦠 Infection risk
Do not change from 5MG to 10MG or vice versa without medical advice.
Tofacitinib affects immune-system activity and therefore requires careful medical supervision.
Tofacitinib may increase susceptibility to infections, including:
✔️ Tuberculosis
✔️ Bacterial infections
✔️ Fungal infections
✔️ Viral infections
✔️ Opportunistic infections
Your doctor may screen for tuberculosis and other infections before starting treatment.
Tell your doctor if you have fever, persistent cough, unexplained weight loss, or other symptoms of infection.
JAK inhibitors have been associated with an increased risk of certain serious cardiovascular events in particular higher-risk patients.
Tell your healthcare professional if you have risk factors such as:
❤️ Previous heart attack
🩸 Previous stroke
🚬 Smoking
🩺 High blood pressure
🩸 High cholesterol
Your doctor will determine whether Tofacitinib is appropriate for you.
Tofacitinib has been associated with an increased risk of serious blood clots, particularly in certain higher-risk patients and at higher doses.
Seek urgent medical care for:
🚨 Sudden chest pain
🚨 Difficulty breathing
🚨 Sudden shortness of breath
🚨 Painful swelling in one leg
Tofacitinib may increase the risk of certain cancers, including lymphoma and other malignancies.
Your doctor will evaluate your individual risk factors and monitor you appropriately.
Your healthcare professional may periodically monitor:
🩸 Complete blood count (CBC)
🧪 Liver function tests
🩸 Cholesterol and lipid levels
🦠 Tuberculosis screening
🦠 Other infection screening when appropriate
Regular appointments and laboratory testing are important during long-term treatment.
Possible side effects may include:
✔️ Upper respiratory tract infections
✔️ Headache
✔️ Diarrhea
✔️ Increased cholesterol
✔️ Increased blood pressure
✔️ Changes in blood cell counts
✔️ Herpes zoster (shingles)
✔️ Liver enzyme abnormalities
More serious complications are less common but can include serious infections, blood clots, major cardiovascular events, and malignancies.
🚨 Severe chest pain
🚨 Sudden difficulty breathing
🚨 Sudden weakness or difficulty speaking
🚨 A painful or swollen leg
🚨 Persistent high fever
🚨 Severe infection symptoms
Tell your doctor about every medicine, supplement, or herbal product you use.
Special attention may be required when Tofacitinib is combined with:
🔹 Other JAK inhibitors
🔹 Biologic immunosuppressants
🔹 Potent immunosuppressive medicines
🔹 Certain medicines that affect CYP enzymes
Discuss vaccination with your doctor before starting treatment.
⚠️ Live vaccines are generally avoided during Tofacitinib treatment.
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TOFANIB 5MG TABLET by HORIZON PHARMA contains Tofacitinib 5MG, a JAK inhibitor used for selected patients with inflammatory and autoimmune conditions including rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.
Tofacitinib works by reducing specific cytokine signaling through the JAK pathway, helping control excessive immune activity and inflammation.
Because Tofacitinib can increase the risk of serious infections, blood clots, cardiovascular events, and certain cancers, it should be used only under appropriate medical supervision.
⚠️ Prescription medicine – do not start, stop, or change the dose without your doctor's advice.
✔️ TOFANIB 5MG contains Tofacitinib, a JAK inhibitor used for selected inflammatory conditions such as rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.
✔️ No. Tofacitinib is not a corticosteroid. It belongs to the Janus kinase (JAK) inhibitor class and works by modifying specific immune signaling pathways.
✔️ Both contain Tofacitinib, but the strengths differ. The appropriate strength and dosing schedule depend on the condition being treated and factors such as kidney function, liver function, and treatment response. Do not change strengths without medical advice.
✔️ Yes. Tofacitinib modifies immune-system activity and can increase the risk of infections. Appropriate screening and monitoring are important during treatment.
📢 TOFANIB 5MG TABLET by HORIZON PHARMA is available through SuperCare Pharma, subject to product availability and applicable prescription requirements.
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⚠️ Prescription medicine – use only under the supervision of a qualified healthcare professional.
