ACTINIB 5MG TABLET by SEARLE PHARMA contains Tofacitinib 5MG, a prescription Janus kinase (JAK) inhibitor used to manage selected inflammatory and autoimmune conditions. Tofacitinib works by reducing specific immune-system signaling pathways that contribute to inflammation.
It may be prescribed for appropriately selected adults with conditions such as rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. Since Tofacitinib affects immune-system activity and carries important safety considerations, it should be used only under the supervision of a qualified healthcare professional.
✔️ Helps Control Inflammation – Tofacitinib reduces specific immune signaling pathways involved in inflammatory diseases.
✔️ Rheumatoid Arthritis Management – Used in appropriately selected adults with moderately to severely active rheumatoid arthritis.
✔️ Psoriatic Arthritis Treatment – May help reduce inflammatory activity and improve symptoms associated with active psoriatic arthritis.
✔️ Ulcerative Colitis Management – Used in certain adults with moderately to severely active ulcerative colitis.
✔️ Modulates Immune Signaling – Works through the JAK pathway to regulate excessive cytokine signaling.
✔️ Supports Joint Function – Controlling inflammatory activity may help improve joint pain, swelling, stiffness, and physical function.
✔️ Convenient Oral Tablet – Provides an oral treatment option when prescribed by a healthcare professional.
✔️ Non-Steroidal Treatment – Tofacitinib is a JAK inhibitor, not a corticosteroid.
Tofacitinib belongs to the Janus kinase inhibitor class, commonly known as JAK inhibitors.
JAK enzymes help transmit signals from cytokines involved in immune and inflammatory responses. Excessive activity in these pathways can contribute to chronic inflammation and autoimmune disease.
Tofacitinib inhibits JAK activity, particularly JAK1 and JAK3, reducing signaling through several cytokine pathways.
🧬 Inflammatory cytokines
⬇️
⚡ JAK signaling pathway
⬇️
🔥 Excess immune activity
⬇️
💊 Tofacitinib inhibits JAK signaling
⬇️
📉 Reduced inflammatory signaling
⬇️
🦴 Better control of inflammatory disease
Rheumatoid arthritis (RA) is an autoimmune condition that causes inflammation in and around the joints.
Common symptoms include:
🔹 Joint pain
🔹 Swelling
🔹 Morning stiffness
🔹 Reduced mobility
🔹 Fatigue
🔹 Difficulty with daily activities
Tofacitinib may be prescribed for appropriately selected adults with moderately to severely active rheumatoid arthritis when other suitable treatments have not provided sufficient benefit or have not been tolerated.
By controlling inflammatory signaling, treatment may help improve:
✔️ Joint symptoms
✔️ Physical function
✔️ Disease activity
✔️ Daily mobility
Psoriatic arthritis is an inflammatory form of arthritis associated with psoriasis.
It can affect:
🖐️ Hands
🦶 Feet
🦵 Knees
🦴 Spine
💅 Nails
🦶 Fingers and toes
Tofacitinib may be prescribed for selected adults to help control inflammatory disease activity and improve symptoms.
Potential benefits may include:
✔️ Reduced joint inflammation
✔️ Improved physical function
✔️ Reduced stiffness
✔️ Better mobility
Ulcerative colitis is a chronic inflammatory bowel disease affecting the lining of the colon.
Symptoms can include:
🔹 Frequent diarrhea
🔹 Rectal bleeding
🔹 Abdominal discomfort
🔹 Urgency to pass stool
🔹 Inflammation of the colon
Tofacitinib may be used for certain adults with moderately to severely active ulcerative colitis under a physician-directed treatment plan.
🌟 Contains Tofacitinib 5MG – An established JAK inhibitor used for selected inflammatory conditions.
🧬 Targeted JAK Pathway – Modulates immune signaling involved in inflammatory responses.
💊 Convenient Tablet Form – Easy oral administration according to the prescribed regimen.
🏭 SEARLE PHARMA – ACTINIB is supplied under the SEARLE PHARMA brand.
📦 10-Tablet Pack – Convenient pack size.
🩺 Medical Supervision Required – Appropriate screening and monitoring are important during Tofacitinib treatment.
⚠️ Take ACTINIB exactly as prescribed by your doctor.
✔️ Swallow the tablet with water.
✔️ It may generally be taken with or without food.
✔️ Follow the exact dosing schedule provided by your healthcare professional.
✔️ Take it consistently according to your prescribed schedule.
✔️ Do not take more than prescribed.
✔️ Do not stop treatment without speaking with your doctor.
✔️ Do not change the strength or frequency without medical advice.
The appropriate Tofacitinib dosage depends on the condition being treated, treatment phase, kidney function, liver function, age, other medicines, and individual risk factors.
Therefore, ACTINIB 5MG should only be used according to your doctor's prescription.
Tofacitinib affects immune-system function and may increase the risk of serious infections.
These can include:
🔹 Tuberculosis
🔹 Bacterial infections
🔹 Fungal infections
🔹 Viral infections
🔹 Opportunistic infections
Your doctor may screen you for tuberculosis and other infections before starting treatment.
Tell your doctor if you have an active infection or develop persistent fever, cough, unusual fatigue, or other signs of infection.
JAK inhibitors have been associated with an increased risk of certain serious cardiovascular events, particularly in patients with additional risk factors.
Inform your doctor if you have:
❤️ Heart disease
🩸 Previous heart attack
🧠 Previous stroke
🚬 Smoking history
🩺 High blood pressure
🩸 High cholesterol
Your healthcare professional will determine whether Tofacitinib is appropriate for you.
Tofacitinib has been associated with serious blood clots in certain patients.
Seek urgent medical attention if you experience:
🚨 Sudden chest pain
🚨 Difficulty breathing
🚨 Sudden shortness of breath
🚨 Painful swelling of one leg
Tofacitinib may increase the risk of certain malignancies, including lymphoma and other cancers.
Your doctor will consider your individual risk factors and monitor you appropriately.
Your healthcare professional may recommend regular monitoring of:
🩸 Complete blood count (CBC)
🧪 Liver function tests
🩸 Cholesterol/lipid levels
🦠 Tuberculosis screening
🦠 Other infection screening when appropriate
Regular follow-up is important during long-term therapy.
Possible side effects may include:
✔️ Upper respiratory tract infections
✔️ Headache
✔️ Diarrhea
✔️ Increased cholesterol levels
✔️ Increased blood pressure
✔️ Changes in blood cell counts
✔️ Herpes zoster (shingles)
✔️ Changes in liver enzymes
Serious complications such as severe infections, blood clots, cardiovascular events, or malignancies require prompt medical evaluation.
🚨 Severe chest pain
🚨 Sudden difficulty breathing
🚨 Sudden weakness or difficulty speaking
🚨 Painful or swollen leg
🚨 Persistent high fever
🚨 Severe infection symptoms
Tell your doctor about all prescription medicines, OTC medicines, supplements, and herbal products you use.
Special caution may be required with:
🔹 Other JAK inhibitors
🔹 Biologic immunosuppressants
🔹 Potent immunosuppressive medicines
🔹 Certain medicines affecting CYP enzymes
Discuss vaccinations with your healthcare professional before starting treatment.
⚠️ Live vaccines are generally avoided during Tofacitinib treatment unless specifically recommended by your doctor.
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ACTINIB 5MG TABLET by SEARLE PHARMA contains Tofacitinib 5MG, a prescription JAK inhibitor used for selected inflammatory and autoimmune conditions including rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.
By modifying JAK-dependent cytokine signaling, Tofacitinib helps regulate excessive immune activity and inflammatory responses.
Because this medicine can increase the risk of serious infections and other significant complications, ACTINIB should only be used under appropriate medical supervision.
⚠️ Prescription medicine – do not start, stop, or change your dose without consulting your healthcare professional.
✔️ ACTINIB 5MG contains Tofacitinib, a JAK inhibitor used for selected inflammatory conditions such as rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.
✔️ No. ACTINIB contains Tofacitinib, which is a Janus kinase (JAK) inhibitor, not a corticosteroid.
✔️ Tofacitinib may be prescribed to reduce inflammatory disease activity and improve joint symptoms and physical function in appropriately selected adults with rheumatoid arthritis.
✔️ No. Tofacitinib is a prescription medicine that requires medical evaluation and monitoring because it can increase the risk of serious infections and other complications.
📢 ACTINIB 5MG TABLET by SEARLE PHARMA is available through SuperCare Pharma, subject to availability and applicable prescription requirements.
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⚠️ Prescription medicine – use only under the supervision of a qualified healthcare professional.
