TOFAMAG 5MG TABLET by CRYSTOLITE contains Tofacitinib 5MG, a prescription Janus kinase (JAK) inhibitor used to manage selected inflammatory and autoimmune conditions. Tofacitinib works by reducing specific immune-system signaling pathways that contribute to inflammation.
It may be prescribed for conditions including rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis in appropriately selected patients. Because Tofacitinib affects immune-system activity and has important safety considerations, it should be used only under the supervision of a qualified healthcare professional.
✔️ Helps Control Inflammation – Tofacitinib reduces specific immune signaling involved in inflammatory diseases.
✔️ Rheumatoid Arthritis Management – Used for appropriately selected adults with moderately to severely active rheumatoid arthritis.
✔️ Psoriatic Arthritis Treatment – May help reduce inflammation and symptoms associated with active psoriatic arthritis.
✔️ Ulcerative Colitis Management – Used in selected adults with moderately to severely active ulcerative colitis.
✔️ Reduces Inflammatory Signaling – Works through the JAK pathway to modify excessive immune activity.
✔️ Supports Joint Function – In inflammatory arthritis, controlling disease activity may help improve pain, stiffness, swelling, and physical function.
✔️ Convenient Oral Form – Available as an easy-to-administer tablet.
✔️ Non-Steroidal Treatment – Tofacitinib is a targeted JAK inhibitor, not a corticosteroid.
Tofacitinib belongs to a class of medicines called Janus kinase inhibitors, commonly known as JAK inhibitors.
JAK enzymes help transmit signals from various cytokines involved in immune and inflammatory responses. Excessive cytokine signaling can contribute to chronic inflammation and autoimmune disease.
Tofacitinib inhibits JAK activity, particularly JAK1 and JAK3, reducing signaling through several inflammatory pathways.
🧬 Inflammatory signals
⬇️
⚡ JAK pathway activation
⬇️
🔥 Excess immune activity
⬇️
💊 Tofacitinib inhibits JAK signaling
⬇️
📉 Reduced inflammatory signaling
⬇️
🦴 Better control of inflammatory disease
Rheumatoid arthritis (RA) is an autoimmune disease that causes inflammation in the joints.
Symptoms may include:
🔹 Joint pain
🔹 Swelling
🔹 Morning stiffness
🔹 Reduced movement
🔹 Fatigue
🔹 Difficulty performing daily activities
Tofacitinib may be prescribed for adults with moderately to severely active rheumatoid arthritis when other appropriate treatments have not provided sufficient benefit or have not been tolerated.
By controlling inflammatory signaling, it may help improve:
✔️ Joint symptoms
✔️ Physical function
✔️ Disease activity
✔️ Daily mobility
Psoriatic arthritis is an inflammatory condition associated with psoriasis that can affect the joints, skin, nails, fingers, toes, and spine.
Tofacitinib may help reduce inflammatory activity in appropriately selected patients.
Potential improvements can include:
✔️ Reduced joint inflammation
✔️ Improved joint function
✔️ Less stiffness
✔️ Better physical mobility
Treatment should be individualized according to the patient's disease severity and medical history.
Ulcerative colitis is a chronic inflammatory bowel disease affecting the lining of the colon.
Common symptoms include:
🔹 Frequent diarrhea
🔹 Rectal bleeding
🔹 Abdominal discomfort
🔹 Urgency to pass stool
🔹 Bowel inflammation
Tofacitinib may be used in certain adults with moderately to severely active ulcerative colitis according to a physician-directed treatment plan.
🌟 Contains Tofacitinib 5MG – An established JAK inhibitor used for selected inflammatory conditions.
🧬 Targeted Immune Signaling – Acts on JAK-dependent pathways involved in cytokine signaling.
💊 Convenient Tablet Form – Oral treatment that can be taken according to your prescribed regimen.
🏭 CRYSTOLITE – TOFAMAG 5MG is supplied under the CRYSTOLITE brand.
📦 10-Tablet Pack – Convenient pack size.
🩺 Medical Supervision – Requires appropriate screening and monitoring because of its immune-modulating effects.
⚠️ Take TOFAMAG 5MG exactly as prescribed by your doctor.
✔️ Swallow the tablet with water.
✔️ It may generally be taken with or without food.
✔️ Take it according to the dosing schedule provided by your healthcare professional.
✔️ Do not take an additional tablet to compensate for a missed dose unless specifically instructed.
✔️ Do not stop treatment without discussing it with your doctor.
✔️ Do not change from 5MG to another strength without medical advice.
The correct Tofacitinib dose depends on the medical condition, treatment stage, kidney function, liver function, age, other medicines, and individual risk factors.
The 5MG tablet should therefore be used only according to the prescribed regimen.
Because Tofacitinib affects immune-system activity, it can increase the risk of serious infections.
These may include:
🔹 Tuberculosis
🔹 Bacterial infections
🔹 Fungal infections
🔹 Viral infections
🔹 Opportunistic infections
Doctors may screen patients for tuberculosis and other infections before starting treatment.
Tell your doctor if you have an active infection or develop persistent fever, cough, or other signs of infection.
JAK inhibitors have been associated with an increased risk of certain serious cardiovascular events, particularly in patients with additional risk factors.
Tell your doctor if you have:
❤️ A history of heart disease
🩸 Previous heart attack
🧠 Previous stroke
🚬 Smoking history
🩺 High blood pressure
🩸 High cholesterol
Your healthcare professional will determine whether Tofacitinib is appropriate for you.
Tofacitinib has been associated with an increased risk of serious blood clots in certain patients.
Seek urgent medical attention if you develop:
🚨 Sudden chest pain
🚨 Difficulty breathing
🚨 Sudden shortness of breath
🚨 Painful swelling of one leg
Tofacitinib may increase the risk of certain malignancies, including lymphoma and other cancers.
Your doctor will evaluate your individual risk factors before and during treatment.
Your doctor may recommend regular monitoring such as:
🩸 Complete blood count (CBC)
🧪 Liver function tests
🩸 Cholesterol/lipid levels
🦠 Tuberculosis screening
🦠 Other infection screening when appropriate
Regular follow-up is especially important during long-term therapy.
Some patients may experience:
✔️ Upper respiratory tract infections
✔️ Headache
✔️ Diarrhea
✔️ Increased cholesterol
✔️ Increased blood pressure
✔️ Changes in blood cell counts
✔️ Herpes zoster (shingles)
✔️ Increased liver enzymes
Serious adverse effects such as severe infections, blood clots, major cardiovascular events, or malignancies require prompt medical evaluation.
🚨 Severe chest pain
🚨 Sudden difficulty breathing
🚨 Sudden weakness or difficulty speaking
🚨 Painful or swollen leg
🚨 Persistent high fever
🚨 Severe infection symptoms
Always inform your doctor about all prescription medicines, OTC medicines, supplements, and herbal products you use.
Special caution may be required with:
🔹 Other JAK inhibitors
🔹 Biologic immunosuppressants
🔹 Potent immunosuppressive medicines
🔹 Certain medicines that affect CYP enzymes
Discuss vaccination with your doctor before starting Tofacitinib.
⚠️ Live vaccines are generally avoided during treatment unless specifically recommended by your healthcare professional.
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TOFAMAG 5MG TABLET by CRYSTOLITE contains Tofacitinib 5MG, a prescription JAK inhibitor used for selected inflammatory and autoimmune conditions.
Its targeted action on JAK-dependent immune signaling can help reduce excessive inflammatory activity in conditions such as rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.
Because Tofacitinib can increase the risk of infections and other serious complications, it should be taken only under appropriate medical supervision with recommended screening and monitoring.
⚠️ Prescription medicine – do not start, stop, or change your dose without consulting your doctor.
✔️ TOFAMAG 5MG contains Tofacitinib, a JAK inhibitor used for selected inflammatory conditions including rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.
✔️ No. Tofacitinib is not a steroid or corticosteroid. It is a Janus kinase (JAK) inhibitor that modifies specific immune signaling pathways.
✔️ It may be prescribed to reduce inflammatory disease activity and improve joint symptoms and physical function in appropriately selected adults with rheumatoid arthritis.
✔️ No. Tofacitinib is a prescription medicine and should only be used after evaluation by a qualified healthcare professional because it can cause serious adverse effects and requires appropriate monitoring.
📢 TOFAMAG 5MG TABLET by CRYSTOLITE is available through SuperCare Pharma, subject to availability and applicable prescription requirements.
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⚠️ Prescription medicine – use only under the supervision of a qualified healthcare professional.
