TOFANIB 10MG TABLET by HORIZON PHARMA contains Tofacitinib 10MG, a prescription medicine belonging to the Janus kinase (JAK) inhibitor class. Tofacitinib works by reducing specific immune-system signals involved in inflammation and is used for selected inflammatory and autoimmune conditions.
Tofacitinib may be prescribed for conditions such as rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis in appropriate patients. Because JAK inhibitors can have important safety risks, treatment should be started and monitored by a qualified healthcare professional.
✔️ Reduces Inflammatory Activity – Tofacitinib suppresses specific immune signaling pathways involved in chronic inflammation.
✔️ Rheumatoid Arthritis Treatment – May be prescribed for adults with moderately to severely active rheumatoid arthritis when appropriate.
✔️ Psoriatic Arthritis Management – Can help control symptoms and inflammation associated with active psoriatic arthritis in suitable patients.
✔️ Ulcerative Colitis Treatment – Tofacitinib is also used for appropriately selected adults with moderately to severely active ulcerative colitis.
✔️ Helps Improve Joint Symptoms – In inflammatory arthritis, reducing immune signaling can help improve pain, swelling, stiffness, and physical function.
✔️ Oral Treatment Option – Available as a convenient tablet rather than an injection.
✔️ Targeted Immune Modulation – Works on JAK-dependent signaling pathways involved in inflammatory and immune responses.
Tofacitinib is a JAK inhibitor.
The JAK pathway is involved in transmitting signals from various inflammatory cytokines. Excessive cytokine signaling can contribute to inflammation and tissue damage in autoimmune and inflammatory diseases.
Tofacitinib inhibits JAK enzymes, particularly JAK1 and JAK3, thereby reducing signaling from certain cytokines.
🧬 Inflammatory cytokines
⬇️
⚡ JAK signaling pathway activated
⬇️
🔥 Increased immune/inflammatory activity
⬇️
💊 Tofacitinib inhibits JAK signaling
⬇️
📉 Reduced inflammatory signaling
⬇️
🦴 Improved control of inflammatory disease symptoms
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that can cause:
🔹 Joint pain
🔹 Swelling
🔹 Morning stiffness
🔹 Reduced mobility
🔹 Progressive joint damage
Tofacitinib may be prescribed for adults with moderately to severely active RA who have had an inadequate response or intolerance to certain other treatments.
It may help improve:
✔️ Joint symptoms
✔️ Physical function
✔️ Disease activity
✔️ Overall quality of life
Treatment decisions should always be individualized by a rheumatologist or other qualified healthcare professional.
Psoriatic arthritis can cause inflammation in the:
🦴 Joints
🖐️ Fingers and toes
🦶 Feet
🦵 Knees
🧍 Spine
Tofacitinib can help reduce inflammatory activity in appropriate patients with active psoriatic arthritis.
It may help improve:
✔️ Joint pain
✔️ Swelling
✔️ Stiffness
✔️ Physical function
Tofacitinib is also used for certain adults with moderately to severely active ulcerative colitis.
Ulcerative colitis may cause:
🔹 Diarrhea
🔹 Rectal bleeding
🔹 Abdominal discomfort
🔹 Urgency to pass stool
🔹 Inflammation of the colon
By modifying specific immune signaling pathways, Tofacitinib can help reduce inflammatory activity in appropriately selected patients.
🌟 Contains Tofacitinib 10MG – A well-established JAK inhibitor used for selected inflammatory diseases.
🧬 Targeted Immune Pathway – Modulates JAK-dependent cytokine signaling.
💊 Convenient Oral Tablet – No injection required for administration.
🏭 HORIZON PHARMA – TOFANIB is supplied under the HORIZON PHARMA brand.
📦 30-Tablet Pack – Convenient pack size for prescribed treatment.
🩺 Specialist-Supervised Therapy – Appropriate monitoring can help maximize treatment benefits and manage potential risks.
⚠️ Take TOFANIB exactly as prescribed by your doctor.
✔️ Swallow the tablet with water.
✔️ It may generally be taken with or without food.
✔️ Take it at the times recommended by your healthcare professional.
✔️ Do not crush or alter the tablet unless your pharmacist or doctor specifically advises you to do so.
✔️ Do not take more than the prescribed dose.
✔️ If you miss a dose, follow your healthcare professional's instructions rather than taking an extra dose.
Tofacitinib dosing varies according to the medical condition being treated. A 10MG dose is commonly used in certain treatment phases or indications, particularly in ulcerative colitis, but it is not automatically the correct long-term dose for every patient.
Your doctor will determine the appropriate strength and treatment duration based on your condition and risk factors.
Tofacitinib carries important warnings because it modifies the immune system.
Tofacitinib can increase the risk of serious infections, including:
✔️ Tuberculosis
✔️ Bacterial infections
✔️ Fungal infections
✔️ Viral infections
✔️ Opportunistic infections
Tell your doctor if you have an active infection or recurrent infections.
Before treatment, your healthcare professional may screen for tuberculosis and other infections.
JAK inhibitors, including Tofacitinib, have been associated with increased risks of certain serious cardiovascular events in particular higher-risk populations.
Tell your doctor if you have cardiovascular risk factors such as:
❤️ Previous heart attack
🩸 Stroke history
🚬 Smoking history
🩺 High blood pressure
🩸 High cholesterol
Your doctor will determine whether the benefits of treatment outweigh the risks.
Tofacitinib has been associated with an increased risk of blood clots, including deep-vein thrombosis and pulmonary embolism, particularly at higher doses and in patients with additional risk factors.
Seek urgent medical attention for:
🚨 Sudden chest pain
🚨 Difficulty breathing
🚨 Swelling or pain in one leg
🚨 Sudden unexplained shortness of breath
Tofacitinib may increase the risk of certain malignancies, including lymphoma and other cancers.
Your doctor will consider your individual risk factors before and during treatment.
Your healthcare professional may monitor:
🩸 Complete blood count (CBC)
🧪 Liver function
🩸 Cholesterol/lipid levels
🦠 Tuberculosis screening
🦠 Hepatitis screening where appropriate
🩺 Signs of infection
Regular follow-up is important during treatment.
Possible side effects may include:
✔️ Upper respiratory tract infections
✔️ Headache
✔️ Diarrhea
✔️ Increased cholesterol levels
✔️ Increased blood pressure
✔️ Changes in blood counts
✔️ Herpes zoster (shingles)
✔️ Liver enzyme changes
Serious infections, blood clots, cardiovascular events, and malignancies can occur less commonly but require medical attention.
🚨 Difficulty breathing
🚨 Severe chest pain
🚨 Sudden weakness or speech difficulty
🚨 A painful swollen leg
🚨 Persistent high fever
🚨 Severe or unusual infection symptoms
Tell your doctor about all medicines and supplements you take.
Particular attention may be required with:
🔹 Other biologic immunosuppressants
🔹 Other JAK inhibitors
🔹 Potent immunosuppressive medicines
🔹 Certain medicines that affect CYP metabolism
Before starting Tofacitinib, discuss your vaccination status with your doctor.
⚠️ Live vaccines are generally avoided during Tofacitinib treatment.
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TOFANIB 10MG TABLET by HORIZON PHARMA contains Tofacitinib 10MG, a JAK inhibitor used for selected patients with inflammatory and autoimmune diseases such as rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.
By inhibiting JAK-dependent signaling, Tofacitinib helps reduce excessive inflammatory activity and can improve disease control in appropriately selected patients.
Because Tofacitinib affects the immune system and carries important risks, it should be used only under specialist medical supervision with appropriate screening and monitoring.
⚠️ Prescription medicine – do not start, stop, or change the dose without medical advice.
✔️ TOFANIB 10MG contains Tofacitinib, a JAK inhibitor used for selected inflammatory conditions including rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis, depending on the patient's condition and treatment history.
✔️ No. Tofacitinib is not a corticosteroid. It is a Janus kinase (JAK) inhibitor that modifies specific immune signaling pathways.
✔️ Tofacitinib is taken according to a condition-specific dosing schedule. The 10MG strength may be appropriate in certain situations, but the correct dose and duration must be determined by your doctor.
✔️ Yes. Tofacitinib modifies immune-system signaling and can increase susceptibility to infections. Your doctor may perform infection screening and regular monitoring during treatment.
📢 TOFANIB 10MG TABLET by HORIZON PHARMA is available through SuperCare Pharma, subject to product availability and applicable prescription requirements.
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⚠️ Prescription medicine – use only under the supervision of a qualified healthcare professional.
