COMBIGAN Eye Drops 5ml – Brimonidine Tartrate 0.2% + Timolol 0.5% for Glaucoma & Eye Pressure

COMBIGAN Eye Drops 5ml is a prescription ophthalmic solution containing a combination of Brimonidine Tartrate 0.2% and Timolol 0.5%. It is specifically formulated to help reduce elevated intraocular pressure (IOP) in people with glaucoma or ocular hypertension when additional pressure control is required.

Combigan combines two medicines that lower pressure inside the eye through complementary mechanisms. Brimonidine is an alpha-adrenergic receptor agonist that reduces aqueous humour production and increases uveoscleral outflow, while Timolol is a beta-adrenergic receptor blocker that primarily reduces aqueous humour production. Together, these actions help lower elevated intraocular pressure.

The medicine is supplied as a sterile ophthalmic solution in a 5ml dropper bottle and is intended for topical use in the eye. Because Combigan contains timolol, a beta-blocker, it is important to use this medicine only according to the instructions of an ophthalmologist or other qualified healthcare professional.

COMBIGAN Eye Drops 5ml at a Glance

Product Information	Details
Brand Name	COMBIGAN
Dosage Form	Sterile ophthalmic solution / eye drops
Pack Size	5ml
Active Ingredients	Brimonidine Tartrate + Timolol
Brimonidine Strength	0.2%
Timolol Strength	0.5%
Equivalent Concentration	Brimonidine Tartrate 2mg/ml + Timolol 5mg/ml
Drug Class	Antiglaucoma / IOP-lowering medicine
Main Use	Reduction of elevated intraocular pressure
Conditions	Glaucoma and ocular hypertension
Route	Ophthalmic / topical eye use
Prescription Status	Prescription medicine

Official product information confirms that each ml contains 2mg brimonidine tartrate and timolol equivalent to 5mg timolol, supplied in a 5ml bottle.

Key Benefits of COMBIGAN Eye Drops 5ml

1. Helps Lower Elevated Eye Pressure

COMBIGAN is designed to reduce intraocular pressure (IOP), which is an important part of managing glaucoma and ocular hypertension. Persistent elevation of pressure inside the eye can place stress on the optic nerve, so appropriate pressure control is an important part of glaucoma management.

2. Dual-Action Formula

Combigan contains two active ingredients:

• Brimonidine Tartrate 0.2%
• Timolol 0.5%

The two medicines work through complementary mechanisms to provide pressure-lowering effects.

3. Used in Glaucoma Management

Combigan is indicated for reducing elevated IOP in patients with glaucoma when pressure is not adequately controlled with appropriate therapy.

4. Helps Manage Ocular Hypertension

COMBIGAN can also be used to reduce elevated intraocular pressure in people with ocular hypertension, according to the approved product information.

5. Convenient 5ml Eye Drop Bottle

The 5ml sterile ophthalmic solution comes in a dropper bottle designed for topical administration to the affected eye or eyes.

COMBIGAN Eye Drops Uses

COMBIGAN Eye Drops 5ml is used to reduce elevated intraocular pressure in conditions such as:

• Open-angle glaucoma
• Ocular hypertension
• Elevated eye pressure requiring combination therapy
• Glaucoma where pressure is not adequately controlled with a single topical medicine

The official U.S. prescribing information states that Combigan is indicated for reducing elevated IOP in patients with glaucoma or ocular hypertension who require adjunctive or replacement therapy because their IOP is not adequately controlled.

Why controlling eye pressure matters

Glaucoma can damage the optic nerve and may gradually affect vision. Lowering elevated intraocular pressure is one of the principal approaches used to reduce the risk of further glaucoma-related damage.

Important: Combigan controls elevated eye pressure; it does not reverse established optic-nerve damage. Regular ophthalmic examinations remain important for people with glaucoma.

Active Ingredients in COMBIGAN Eye Drops

Brimonidine Tartrate 0.2%

Brimonidine is an alpha-2 adrenergic receptor agonist. It helps lower intraocular pressure by reducing aqueous humour formation and increasing uveoscleral outflow.

Role of Brimonidine

Brimonidine contributes to:

• Reduction of aqueous humour production
• Increased uveoscleral outflow
• Lowering of elevated intraocular pressure

Timolol 0.5%

Timolol is a non-selective beta-adrenergic receptor blocker. In the eye, it lowers intraocular pressure primarily by reducing the production of aqueous humour.

Role of Timolol

Timolol contributes to:

• Reduced aqueous humour production
• Lower intraocular pressure
• Complementary pressure-lowering activity alongside brimonidine

How Does COMBIGAN Work?

The eye continuously produces a clear fluid called aqueous humour. This fluid normally circulates through the front portion of the eye and drains through natural outflow pathways.

When the balance between production and drainage is disrupted, pressure inside the eye may become elevated.

COMBIGAN combines two mechanisms:

Brimonidine → reduces aqueous humour production + increases uveoscleral outflow

Timolol → reduces aqueous humour production

Together, these effects reduce the amount of fluid contributing to intraocular pressure and therefore help lower elevated IOP.

COMBIGAN Eye Drops Dosage

The commonly recommended adult dose is:

One drop in the affected eye(s) twice daily, approximately 12 hours apart.

However, your ophthalmologist's prescribed dosage should always take priority.

Do not increase the number of drops or frequency of administration because you believe that more drops will lower eye pressure faster.

If you use other eye drops

If you are using another topical ophthalmic medicine, the products should generally be administered at least 5 minutes apart.

How to Use COMBIGAN Eye Drops

Follow your ophthalmologist's instructions carefully.

Step-by-step application

1. Wash your hands thoroughly.
2. Shake or prepare the bottle according to the product instructions.
3. Remove the cap without touching the dropper tip.
4. Tilt your head backward.
5. Gently pull down the lower eyelid to create a small pocket.
6. Hold the bottle above the eye.
7. Instill one prescribed drop into the affected eye.
8. Avoid touching the eye, eyelashes, eyelids, or other surfaces with the dropper tip.
9. Close the eye gently.
10. If instructed, gently press the inner corner of the eye near the nose for a short period to reduce drainage into the nose and systemic absorption.
11. Replace the cap securely.
12. Wash your hands again if necessary.

Avoid squeezing the bottle excessively or administering additional drops unless instructed.

Important Tips for Using COMBIGAN

Do Not Touch the Dropper Tip

Do not allow the dropper tip to touch your:

• Eye
• Eyelashes
• Eyelid
• Fingers
• Other surfaces

Touching the tip can contaminate the sterile solution.

Do Not Share Your Eye Drops

COMBIGAN should not be shared with another person, even if they have similar eye-pressure problems.

Take It at Regular Intervals

If prescribed twice daily, try to use the drops approximately 12 hours apart, as directed.

COMBIGAN and Contact Lenses

COMBIGAN contains benzalkonium chloride, a preservative that may be absorbed by soft contact lenses and can cause lens discoloration. Contact lenses should be removed before administration. The product information advises waiting at least 15 minutes after using Combigan before reinserting soft contact lenses.

COMBIGAN Eye Drops Side Effects

Like all medicines, COMBIGAN may cause side effects.

Possible eye-related effects may include:

• Eye irritation
• Eye redness
• Burning or stinging
• Dry eyes
• Itching
• Foreign-body sensation
• Blurred vision
• Eye discomfort

Because Combigan contains timolol, systemic beta-blocker-related effects can also occur in some patients.

Possible systemic effects can include:

• Slow heart rate
• Low blood pressure
• Dizziness
• Fatigue
• Breathing difficulties
• Weakness

Seek medical attention promptly if you experience difficulty breathing, severe dizziness, fainting, unusually slow heartbeat, severe allergic reaction, or significant changes in vision.

Important Precautions Before Using COMBIGAN

Tell your doctor before using COMBIGAN if you have:

• Asthma
• A history of asthma
• Severe chronic obstructive pulmonary disease (COPD)
• Slow heart rate
• Heart conduction problems
• Heart failure
• Low blood pressure
• Circulation problems
• Diabetes
• Thyroid disease
• Depression or other relevant medical conditions
• Kidney or liver problems
• A known allergy to brimonidine, timolol, or any component of the medicine

The official prescribing information specifically lists bronchial asthma, a history of bronchial asthma, severe COPD, sinus bradycardia, certain heart conduction disorders, overt cardiac failure, cardiogenic shock, and hypersensitivity among contraindications.

COMBIGAN and Asthma

Extra caution is required because COMBIGAN contains timolol, a beta-blocker.

Timolol can affect beta receptors outside the eye after systemic absorption and may cause bronchospasm in susceptible individuals.

COMBIGAN is contraindicated in patients with bronchial asthma, a history of bronchial asthma, and severe COPD according to the prescribing information.

If you have asthma or significant breathing disease, tell your ophthalmologist before using Combigan.

COMBIGAN and Heart Conditions

Because timolol is a beta-blocker, it can affect cardiovascular function.

Tell your doctor if you have:

• Slow pulse
• Heart block
• Heart failure
• Low blood pressure
• Other heart rhythm problems

COMBIGAN is contraindicated in certain significant cardiovascular conditions, including sinus bradycardia, second- or third-degree atrioventricular block, overt cardiac failure, and cardiogenic shock.

COMBIGAN During Pregnancy

If you are pregnant, planning pregnancy, or think you may be pregnant, consult your ophthalmologist before using COMBIGAN.

Do not start, stop, or change glaucoma treatment during pregnancy without professional medical advice.

Your doctor will consider the importance of controlling eye pressure together with the potential risks and benefits of treatment.

COMBIGAN While Breastfeeding

Tell your doctor if you are breastfeeding.

Because COMBIGAN contains timolol and brimonidine, your healthcare professional should determine whether the medicine is appropriate during breastfeeding.

COMBIGAN for Children

COMBIGAN is not intended to be used casually in children.

The product information states that Combigan is contraindicated in neonates and infants younger than 2 years. Pediatric use requires appropriate specialist medical assessment.

Do not administer Combigan to a child unless it has been specifically prescribed.

COMBIGAN Drug Interactions

Tell your doctor about all medicines you take, including prescription medicines, over-the-counter medicines, eye drops, and supplements.

Particular attention may be needed with:

• Other beta-blockers
• Other glaucoma medicines
• Medicines that lower blood pressure
• Medicines affecting heart rhythm
• Certain calcium-channel blockers
• Medicines that slow the heart rate
• Monoamine oxidase inhibitors
• Tricyclic antidepressants
• Other medicines with sedative or cardiovascular effects

Because both active ingredients can have systemic effects, your ophthalmologist should know about your complete medication list.

Can COMBIGAN Be Used With Other Eye Drops?

Yes, a doctor may prescribe Combigan together with other ophthalmic medicines when additional pressure control is required.

However, different eye drops should generally be separated by at least 5 minutes to reduce the likelihood of one medication washing out the other.

Always follow the exact schedule provided by your ophthalmologist.

What If You Miss a Dose of COMBIGAN?

If you forget a dose, use it when you remember unless it is nearly time for your next scheduled dose.

If it is almost time for the next dose, skip the missed dose and continue with your regular schedule.

Do not use two doses at once to compensate for a missed dose.

If you frequently forget your eye drops, ask your ophthalmologist or pharmacist for strategies to help maintain your treatment schedule.

COMBIGAN Overdose

Using substantially more COMBIGAN than prescribed can increase exposure to brimonidine and timolol.

Accidental excessive use may potentially produce symptoms such as:

• Dizziness
• Slow heartbeat
• Low blood pressure
• Weakness
• Breathing difficulties
• Drowsiness

If you accidentally administer a large amount or swallow the contents, seek medical advice promptly.

How to Store COMBIGAN Eye Drops

Store COMBIGAN according to the storage instructions on the product packaging.

Official product information specifies storage below 25°C and protected from light for the referenced formulation. Keep the bottle tightly closed and avoid contaminating the dropper tip.

After Opening

The product information states that the bottle should be discarded 4 weeks after opening, even if some solution remains.

Always follow the instructions on the specific pack you receive.

COMBIGAN Eye Drops 5ml – Product Specifications

Specification	Details
Product	COMBIGAN Eye Drops
Pack Size	5ml
Form	Sterile ophthalmic solution
Brimonidine Tartrate	0.2%
Timolol	0.5%
Brimonidine Tartrate per ml	2mg
Timolol per ml	5mg
Preservative	Benzalkonium chloride
Drug Category	Antiglaucoma medicine
Main Action	Reduces elevated intraocular pressure
Main Conditions	Glaucoma and ocular hypertension
Route	Ophthalmic
Prescription	Yes

The 0.2%/0.5% strength and 5ml presentation are confirmed by official product information.

Why Choose COMBIGAN Eye Drops 5ml?

COMBIGAN provides a dual-ingredient approach to elevated intraocular pressure, combining brimonidine and timolol in one ophthalmic solution.

Instead of using separate bottles for these two active ingredients, the combination provides both mechanisms in a single prescribed eye drop.

Product Highlights

• Contains Brimonidine Tartrate 0.2%
• Contains Timolol 0.5%
• 5ml sterile ophthalmic solution
• Designed to reduce elevated intraocular pressure
• Used in glaucoma and ocular hypertension
• Convenient twice-daily regimen when prescribed
• Combines two complementary IOP-lowering mechanisms
• Prescription ophthalmic medicine

Frequently Asked Questions About COMBIGAN Eye Drops 5ml

What is COMBIGAN Eye Drop?

COMBIGAN is a prescription eye drop containing Brimonidine Tartrate 0.2% and Timolol 0.5%. It is used to reduce elevated intraocular pressure in glaucoma and ocular hypertension.

What is the generic name of COMBIGAN?

COMBIGAN contains the combination of Brimonidine Tartrate + Timolol.

What is COMBIGAN used for?

It is used to lower elevated intraocular pressure in people with glaucoma or ocular hypertension when additional pressure control is required.

What is the strength of COMBIGAN Eye Drops?

COMBIGAN contains:

Brimonidine Tartrate 0.2% + Timolol 0.5%.

How many ml are in COMBIGAN?

The bottle contains 5ml of ophthalmic solution.

How often should COMBIGAN be used?

The standard adult recommended dose is one drop in the affected eye(s) twice daily, approximately 12 hours apart, unless your ophthalmologist gives you different instructions.

Is COMBIGAN used for glaucoma?

Yes. COMBIGAN is indicated for reducing elevated intraocular pressure in glaucoma.

Is COMBIGAN used for high eye pressure?

Yes. It is used for ocular hypertension and elevated intraocular pressure.

Does COMBIGAN cure glaucoma?

COMBIGAN helps control elevated eye pressure. It does not cure glaucoma or restore optic-nerve damage that has already occurred. Continue regular ophthalmologist appointments and use your medicine exactly as prescribed.

Can COMBIGAN be used with other eye drops?

It can be prescribed alongside other eye medicines when clinically appropriate. Different topical ophthalmic medicines should generally be separated by at least 5 minutes.

Can I wear contact lenses while using COMBIGAN?

Remove soft contact lenses before applying the drops because the product contains benzalkonium chloride. Wait at least 15 minutes before putting soft contact lenses back in.

Can people with asthma use COMBIGAN?

COMBIGAN may not be suitable for people with asthma. The product is contraindicated in patients with bronchial asthma or a history of bronchial asthma and in severe COPD.

Can COMBIGAN slow the heartbeat?

Because it contains timolol, a beta-blocker, systemic cardiovascular effects including a slow heartbeat can occur. People with certain heart conditions should not use it unless specifically evaluated by their doctor.

How long can COMBIGAN be used after opening?

The referenced product information states that the bottle should be discarded four weeks after opening.

Is COMBIGAN a prescription medicine?

Yes. Official product information identifies COMBIGAN as a prescription medicine.

Buy COMBIGAN Eye Drops 5ml in Pakistan

Looking for COMBIGAN Eye Drops 5ml in Pakistan? COMBIGAN contains Brimonidine Tartrate 0.2% + Timolol 0.5% and is used under medical supervision to reduce elevated intraocular pressure associated with glaucoma and ocular hypertension.

When purchasing COMBIGAN online, check the:

• Brand name
• 5ml pack size
• Brimonidine 0.2% strength
• Timolol 0.5% strength
• Expiry date
• Packaging integrity
• Manufacturer/marketer information
• Storage condition

Because COMBIGAN is a prescription eye medicine, it should be used according to the treatment plan provided by your ophthalmologist.

Order COMBIGAN Eye Drops 5ml from a trusted pharmacy in Pakistan and use it only as directed by your eye-care professional.

Important Medical Disclaimer

COMBIGAN contains Brimonidine Tartrate and Timolol, prescription medicines used to reduce elevated intraocular pressure. This product information is intended for educational and product-description purposes and does not replace an ophthalmologist's diagnosis or treatment plan.

Do not start, stop, increase, or decrease COMBIGAN without medical advice. If you experience severe eye pain, sudden vision changes, significant breathing difficulty, fainting, severe dizziness, or other serious symptoms, seek urgent medical attention.